ERRα

ERRα

The estrogen-related receptor α (ERRα) is a nuclear receptor and a transcriptional master regulator of mitochondrial function and flexibility, controlling an intricate network of mitochondrial and metabolic genes. ERRα upregulation and activation is associated with poor prognosis, recurrence of cancer, therapy resistance as well as with metastasis of several tumor types including melanoma, breast and colon cancer. The deregulation of energetics in cancer cells is an emerging hallmark of cancer – a hallmark Lead Pharma is targeting with ERRα inverse agonists.

Lead Pharma has developed the very first drug-like series of potent, non-covalent, non-steroidal ERRα inverse agonists.

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